专利名称：Inhibition of gene expression using duplex
forming oligonucleotides
发明人：James McSwiggen,Narendra K. Vaish,Shawn
Zinnen
申请号：US10727780申请日：20031203
公开号：US20050233329A1公开日：20051020
专利附图：
摘要：The present invention concerns methods and nucleic acid based reagents usefulin modulating gene expression in a variety of applications, including use in therapeutic,
veterinary, agricultural, diagnostic, target validation, and genomic discovery applications.Specifically, the invention relates to double strand forming oligonucleotides (DFO) thatcan self assemble to form double stranded oligonucleotides, such as short interferingnucleic acid (siNA), short interfering RNA (siRNA) molecules, and modulate gene
expression, for example by RNA interference (RNAi). The self complementary DFO nucleicacid molecules are useful in the treatment of any disease or condition that responds tomodulation of gene expression or activity in a cell, tissue, or organism.
申请人：James McSwiggen,Narendra K. Vaish,Shawn Zinnen
地址：Boulder CO US,Denver CO US,Denver CO US
国籍：US,US,US
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