Devices, compositions and methods for the pulmonar

专利名称：Devices, compositions and methods for the

pulmonary delivery of aerosolizedmedicaments

发明人：Robert M. Platz,John S. Patton,Linda

Foster,Mohammed Eljamal

申请号：US10245705申请日：20020918

公开号：US20030086877A1公开日：20030508

摘要：According to the subject invention, dispersible dry powder pharmaceutical-based compositions are provided, including methods for their manufacture and drypowder dispersion devices. A dispersible dry powder pharmaceutical-based compositionis one having a moisture content of less than about 10% by weight (%w) water, usuallybelow about 5%w and preferably less than about 3%w; a particle size of about 1.0-5.0&mgr;m mass median diameter (MMD), usually 1.0-4.0 &mgr;m MMD, and preferably 1.0-3.0 &mgr;m MMD; a delivered dose of about >30%, usually >40%, preferably >50%, andmost preferred >60%: and an aerosol particle size distribution of about 1.0-5.0 &mgr;mmass median aerodynamic diameter (MMAD), usually 1.5-4.5 &mgr;m MMAD, andpreferably 1.5-4.0 MMAD. Such composition are of pharmaceutical grade purity.

申请人：PLATZ ROBERT M.,PATTON JOHN S.,FOSTER LINDA,ELJAMAL MOHAMMED

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