专利名称：HETEROCYCLIC SUBSTITUTED CARBONYL
DERIVATIVES AND THEIR USE AS DOPAMINED3 RECEPTOR LIGANDS
发明人：Hendrix, James A.,Hemmerle, Horst,Urmann,
Matthias,Shutske, Gregory M.,Strupczewski,Joseph T.,Bordeau, Kenneth J.,Jurcak, JohnG.,Nieduzak, Thaddeus,Jackson, SharonAnne,Angell, Paul,Carey, James P.,Lee,George E.,Fink, David M.,Sabuco, Jean-Francois,Chiang, Yulin,Collar, Nicola
申请号：EP05018120.5申请日：20020215公开号：EP1632483B1公开日：20081029
摘要：The invention relates to heterocyclic substituted carbonyl derivatives of theformula I that display selective binding to dopamine D receptors and are useful fortreating central nervous system disorders associated with the dopamine D receptoractivity in a patient in need of such treatment comprising administering to the subject atherapeutically effective amount of said compounds for alleviation of such disorder. Thecentral nervous system disorders that may be treated with these compounds includePsychotic Disorders, Substance Dependence, Substance Abuse, Dyskinetic Disorders (e.g.Parkinson's Disease, Parkinsonism, Neuroleptic-Induced Tardive Dyskinesia, Gilles de laTourette Syndrome and Huntington's Disease), Dementia, Anxiety Disorders, Sleep
Disorders, Circadian Rhythm Disorders and Mood Disorders. The subject invention is alsodirected towards processes for the preparation of the compounds described herein aswell as methods for making and using the compounds as imaging agents for dopamine Dreceptors.
申请人：AVENTIS PHARMA INC
地址：US
国籍：US
代理机构：Fischer, Hans-Jürgen
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