Intravenous administration of tramadol

专利名称：Intravenous administration of tramadol发明人：Lucy Lu,Scott Reines,Jeffrey Ping申请号：US15622910申请日：20170614公开号：US09980900B2公开日：20180529

摘要：A method of treating pain, e.g., acute post-operative pain, by administering to ahuman patient(s) a therapeutically effective dose of tramadol intravenously in a dosingregimen which includes one or more loading doses administered at shortened intervalsas compared to dosing at steady-state is disclosed. In preferred embodiments, theintravenous dosing regimen provides a Cmax and AUC of tramadol is similar to the Cmaxand AUC of an oral dose of 100 mg tramadol HCl given every 6 hours. In certainpreferred embodiments, the dosing regimen comprises 50 mg IV tramadol at Hour 0,followed by 50 mg at Hour 2, 50 mg at hour 4, and 50 mg every 4 hours thereafter (e.g.,until the patient no longer requires treatment with tramadol).

申请人：Revogenex Ireland Ltd

地址：Dublin IE

国籍：IE

代理机构：Davidson, Davidson & Kappel LLC

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